I’M GOING TO KEEP TAKING MY RESVERATROL AND NIAGEN, AND THIS SUGGESTS THEY’RE HELPING: Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.

UPDATE: People are acting like this is incomprehensible, but if you click through and read the summary and conclusions it’s pretty straightforward. SIRT1, which is activated by things like resveratrol, protects veins and arteries from hardening and calcification. What’s more, if you block SIRT1 activity, the hardening and calcification get much worse. This doesn’t exactly prove that the supplements I’m taking work — it’s a lab experiment with tissue, not a human body — but it suggests that they do what they’re advertised to do, and that might help.