THIS ISN’T SURPRISING, GIVEN THAT TESTOSTERONE IS A POTENT ANTI-DEPRESSANT: Hormone Therapy for Prostate Cancer Tied to Depression. “Compared with those treated with other therapies, men who received androgen deprivation therapy were 23 percent more likely to receive a diagnosis of depression, and they had a 29 percent increased risk of having inpatient psychiatric treatment. Longer hormone treatment increased the risk.”