December 22, 2013
A new antibody could dramatically boost strength and muscle mass in patients with cancer, chronic obstructive pulmonary disease (COPD), sporadic inclusion body myositis, and in elderly patients with sarcopenia according to research published ahead of print in the journal Molecular and Cellular Biology.
“Age-related loss of muscle mass is a major contributing factor to falls, broken bones, and the loss of mobility,” says co-corresponding author David Glass of Novartis, Cambridge, MA, one of the compound’s developers, along with first author Estelle Trifilieff, also of Novartis. “This study illustrates that we may have a powerful tool to prevent muscle wasting and promote growth.”
The new compound (BYM338) acts to prevent muscle wasting by blocking a receptor that engages a cellular signaling system that exists to put the brakes on muscle development when appropriate. But sometimes those brakes are activated inappropriately, or are stuck on.
“Our goal was to release the brakes,” says Glass.
How long before bodybuilders start trying it out?