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What Are the Dangers in Screening for Diseases?

shutterstock_130094336 Can colonoscopies sometimes do more harm than good?

It will probably by now not come as a surprise to readers to learn that the Danish researchers found reports of experiments on screening procedures to be peculiarly lacking in details about the harmful effects of those procedures. They considered reports on 57 trials for screening for several different kinds of cancer (that is, all those that had been done in the world to an acceptable standard), using ten different technological techniques.

These trials involved 3,416,036 participants. They looked to see whether the reports contained quantified evidence about seven possible harms of screening: overdiagnosis, false positive findings, bodily complications from screening procedures, negative psychosocial consequences of screening, additional numbers of invasive procedures consequent upon screening, all-cause mortality (important because extra surgical procedures, for example, would have a mortality rate), and the withdrawal of participants because of complications of the screening procedures. It is necessary to know these things before a doctor can properly advise a patient to have a screening procedure, or before a patient can make an informed decision.

In only one of the 57 trials was a figure given for the number of withdrawals from completion of the trial because of complications caused by the screening procedure. In only two trials were the figures given for false positives and four trials for overdiagnosis. This contrasts with 51 trials that measured cancer-specific mortality, the reduction of which is the aim of screening procedures. All-cause mortality -- more important to the patient than cancer-specific mortality -- was measured half as often cancer-specific mortality.

The authors are uncompromising in their conclusion: doctors are recommending procedures on a vast scale on the basis of inadequate knowledge that also precludes informed consent on the part of patients. This is because the harms as well as the benefits of a procedure should be known before recommending or agreeing to it. All the more is this so where the initiative for the procedure comes from the doctor and not from the patient.


images courtesy shutterstock / Tyler Olson / Sebastian Kaulitzki