CHANGE: Long-awaited diet pill gets U.S. approval. “Made by Orexigen Therapeutics Inc, Contrave is a combination of the antidepressant bupropion and Orexigen’s formulation of naltrexone, designed to prevent drug dependence.”
Personally, I’d try the Gary Taubes approach first, leavened with some Mark Rippetoe. But that’s just me.