Pakistan is irrelevant, as long as we can get the nukes. No nukes, Pakistan is just somalia, who cares?
The current administation appears to understand this and have a sense of priorities. This is unlike Mr Bush who was both incompetent and easily fooled.
Nukes are complex machines. We can hope the people in charge of nukes in Pakistan will choose to take a deal and live in the west, rather than the 7th century. Trying to seize them without internal help is difficult as the Paks are expecting it.
Mr Obama may turn out to be Jimmy Two but there is no evidence yet to support that idea.